Archer’s annual STEM Symposium is an opportunity for Los Angeles high school students who have completed independent or small group projects in STEM to present their findings. Students are invited to present their research in the fields of molecular biology, chemistry, physics, and engineering.

The Archer RISE Award honors exceptional young women for their innovative scientific research or engineering design projects that further existing knowledge or develop solutions to pressing scientific challenges. Finalists for the RISE Award are noted in throughout the online program and will be awarded at lunch on May 21.

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Saturday, May 21 • 9:15am - 10:30am
The Effects of D-limonene on the Inhibition of Angiogenesis in the Chick Chorioallantoic Membrane

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Many deadly tumors are associated with the overexpression of angiogenesis, the growth of blood vessels from preexisting vasculature. Angiogenesis is overexpressed in vascular tumors, such as breast cancer, glioblastoma, and pancreatic cancer. When angiogenesis is overexpressed, tumor expansion and metastasis occurs. Previous experiments have shown that the inhibition of angiogenesis suppresses tumor growth and metastasis. Antiangiogenic agents, products used to inhibit angiogenesis in tumors, are classified by their ability to target blood supply to tumors by inhibiting their signaling pathways. The vascular endothelial growth factor (VEGF) is one of the signaling pathways for angiogenic targets. Preliminary research has suggested that D-limonene, an oil extracted from a citrus rind, decreases the concentration of PVF-1 (a model for VEGF) in Caenorhabditis elegans at a 50% concentration. This experiment aimed to study the effect of 50% D-limonene concentration on the inhibition of angiogenesis in the Chick Chorioallantoic Membrane. D-limonene was analyzed with the CAM Assay for its efficacy as a natural antiangiogenic agent: the response of blood vessels to D-limonene was quantified microscopically and macroscopically.


Ari Brown

The Archer School for Girls
The Archer School for Girls; Grade 12

Saturday May 21, 2016 9:15am - 10:30am
Dining Hall