Archer’s annual STEM Symposium is an opportunity for Los Angeles high school students who have completed independent or small group projects in STEM to present their findings. Students are invited to present their research in the fields of molecular biology, chemistry, physics, and engineering.

The Archer RISE Award honors exceptional young women for their innovative scientific research or engineering design projects that further existing knowledge or develop solutions to pressing scientific challenges. Finalists for the RISE Award are noted in throughout the online program and will be awarded at lunch on May 21.

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Saturday, May 21 • 11:15am - 11:30am
Effect of Green Coffee Bean Extract on Obesity and Alzheimer[?]s Disease in C. elegans

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Alzheimer[?]s (AD), a neurodegenerative disease suffered nationwide, is the most common form of dementia and worsens as it progresses. Extracellular beta-amyloid protein deposits constitute amyloid plaques in brains that are affected by Alzheimer[?]s. In addition, hyperphosphorylated tau proteins contribute to the plaque build-up through constructing neurofibrillary tangles. No clear treatment has been able to stop the disease or reverse its progression. However, connections between Alzheimer's and obesity have been established to further the search for a cure in AD. The study featured transgenic AD models of C. elegans as test subjects, either individually possessing mutated beta amyloids or hyperphosphorylated tau proteins. A transgenic model possessing the tub-1 gene will serve to measure obesity. Natural homeopathic antioxidants, specifically green coffee bean extract, have been shown to reduce inflammation and weight gain factors in obesity. Through a chemotaxis assay, green coffee bean extract tested the relation between the supplement's ability to suppress weight gain and improve memory conditions in transgenic models of C. elegans at different dosages. The effect of green coffee bean extract on protein buildup in the modified AD C. elegans models was then confirmed through a thioflavin-S staining assay.


Madelyn Arzt

The Archer School for Girls
The Archer School for Girls; Grade 12

Saturday May 21, 2016 11:15am - 11:30am PDT
Room 125

Attendees (1)